Particle Size Control during Ultrasonic Cooling Crystallization of Paracetamol
نویسندگان
چکیده
منابع مشابه
Particle Size and Shape Control in Crystallization Processes
Crystallization from solution is an industrially important unit operation due to its ability to provide high purity separations. The control of the crystal size distribution can be critically important for efficient downstream operations such as filtration and drying, and product effectiveness (e.g., bioavailability, tablet stability). This paper provides an overview on recent developments in t...
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Orthorhombic paracetamol (form II) can be obtained from ethanolic solution when seeding technique is applied although it converts to monoclinic (form I) upon contact with the solvent. In the present work different cooling temperature T(C) (-20, -10 and 0 degrees C) was applied under fixed agitation (700 rpm) and the crystalline product was harvested after different crystallization time t(H) (20...
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Polymorphism is one of the most important issues raised by the industrial crystallization of Active Pharmaceutical Ingredients (API). The dynamic modelling of polymorphic transformations is developed using Femlab, a multiphysics simulation software, which is applied to the resolution of the Populations Balance Equations (PBE) involved. The stable and metastable distinct populations of crystals ...
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ژورنال
عنوان ژورنال: Chemical Engineering & Technology
سال: 2017
ISSN: 0930-7516
DOI: 10.1002/ceat.201600647